Evaluation of Estimated GFR as a Predictor of Diabetic Nephropathy among Type2 Diabetes Mellitus Patients at Zawia Region, Western Libya
Keywords:
T2DM, eGFR, diabetic nephropathy, Cockcroft-Gault equation, Zawia Region.Abstract
Background: Type2 diabetic mellitus (T2DM) patients with impaired renal function and diabetic kidney disease have a higher risk of mortality, and often progress to end-stage renal disease. Objectives: to estimate the glomerular filtration rate using the Cockcroft-Gault (CG) equation, and serum creatinine in the screening of reduced renal function in patients with T2DM in Zawia region Western Libya. Materials and Methods: A cross-sectional study was conducted among 68 type 2 diabetic patients and 67 healthy subjects as control group. Blood samples were tested for fasting blood glucose (FBG), blood urea, and serum creatinine for all patients and control subjects enrolled in this study in the period from January to March 2021. Then eGFR was calculated using Cockcroft- Gault (CG) equation for all patients and control individuals. Results: 68 patients aged 53.26± 13.52years were evaluated 58.8% were women. The mean of serum creatinine is 1.36 mg/dL which is significantly higher as compared with the controls (P value = 0.028). The mean of eGFR showed a significant decreasing in eGFR in diabetic patients compared to healthy subjects (P=0.000). Significantly increased risk of impaired GFR among T2DM patients was observed. 54.4% of patients (n,37) were classified as stage 1 and 27.9% (n,19) as stage 2 and 7.4% (n, 5) as stage 3A and 2.9% (n, 2) as stage 3 B and only 4.4% (n, 3) as stage 5. Study showed significantly decreased in eGFR with increasing of age and duration of diabetes type 2 (P= 0.000& 0.002), respectively. Conclusion: It can be concluded that patients with T2DM enrolled in this study had impaired GFR. This suggested that CKD was a major concern for patients with T2DM. Hence, age of the patient and duration of T2DM had a significant impact in decreasing eGFR.
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